ABSTRACT
Earlier report showed that expression of a splice variant of CD99 transmembrane protein increases invasive ability of human breast cancer cells. Cell motility was also significantly enhanced by the CD99 splice variant expression. In an effort to identify the cellular components that mediate a signal transduction pathway triggered by the CD99 splice variant, known signal path inhibitors were examined for their effects on the motility of the CD99 splice variant-transfected MDA-MB-231 breast cancer cells. Phenylarsine oxide, an inhibitor of phosphatase specific for focal adhesion kinase, and PP1, an inhibitor of src kinase family, significantly suppressed motility of the cells. Among different types of src transfectant clones generated, kinase-negative mutant src transfectant cells were 80% less motile than the mock cells transfected with an empty-vector, while v-src and c-src transfectants exhibited cell motility levels at or slightly above the mock transfectant. These results suggest that src and focal adhesion kinase mediate the intracellular signaling pathway of a CD99 splice variant for the induction of motility of human breast cancer cells.
Subject(s)
Antigens, CD/genetics , Arsenicals/pharmacology , Breast Neoplasms/enzymology , Cell Adhesion Molecules/genetics , Cell Movement/drug effects , Gene Expression , Protein-Tyrosine Kinases/antagonists & inhibitors , Pyrazoles/pharmacology , Pyrimidines/pharmacology , Signal Transduction/drug effects , Transfection , Tumor Cells, Cultured , src-Family Kinases/antagonists & inhibitorsABSTRACT
Polycoria is a rare congenital anomaly of iris. In a wider sense polycoria is including iris dehiscence and iris diastasis as well as true polycoria. A case of binocular iris dehiscence accompanied with congenital anomalies of teeth was reported and literatures were reviewed.
Subject(s)
Iris , Telescopes , ToothABSTRACT
The authors ana lysed statistically seventy-five cases of the eye injuries in childhood under the age of 20 years old during a full year of 1972. 1. Incidence of eye injuries under 20 years old was about 1.1% of total out-patients and 39.9% of total eye injuries. 2. The most common objects to the injury were iron pieces or iron made materials (24%) such as needle, nail, flying iron piece, toy, wire and bar etc. 3. The most common nature of eye injuries was traumatic cataract (14.2%) 4. Seasonally the high peak of injuries was in summer (33.3%) and winter vacation (30.7%) 5. Blindness(under20/200 of corrected VA) was occured finally in 10.8% of total 75 cases.
Subject(s)
Humans , Young Adult , Cataract , Diptera , Eye Injuries , Incidence , Iron , Needles , Outpatients , Play and Playthings , SeasonsABSTRACT
Authors have recently experienced a rare case of avulsion of the left eye ball due to ocular injury in 7 years old Korean girl. The eye ball was completely exposed out of the lid margin. In this case authors supposed that the dynamic inertia was played a major role in the mechanism of avulsion of this eye ball. A breief review of other literatures has also been described.